Introduction: Type 2 diabetes mellitus (T2DM) is the most common metabolic disease worldwide. Early diagnosis of risk groups may help to prevent the development of the disease and many complications related to the disease.
Objective: In this study, we aimed to determine the rate of impaired glucose tolerance (IGT) and T2DM by performing a 75 grams standard oral glucose tolerance test (OGTT) in patients with impaired fasting glucose (IFG).
Materials and Methods: The study included 230 patients (134 female, 96 male) who were admitted to İzmir Tepecik Education and Research Hospital Internal Medicine Outpatient Clinic for general control and were diagnosed with IFG. According to the results of OGTT, the patients were divided into three groups as IFG, IGT and T2DM and the demographic characteristics and the metabolic parameters in the serum were compared.
Results: IFG was seen in 59% (n = 137), IGT 26% (n = 61) and T2DM 13% (n = 32). Waist circumference; In IGT group (median 109 cm) and T2DM group (median 108.5 cm), it was higher than IFG group (median 99 cm) (p <0.001, p = 0.001, respectively). Body mass index (BMI); In IGT group (30.8 kg / m²) and in T2DM group (31 kg / m²), it was higher than IFG group (28 kg / m²) (p = 0.01, p <0.001, respectively). The HOMA-IR level was significantly higher in the IGT group (2.65 mmol / LxU / L) and in the T2DM group (2.82 mmol / LxU / L) than the IFG group (1.68 mmol / LxU / L) (p = 0.001). There was no significant difference between the groups in terms of total cholesterol, triglyceride, HDL and LDL values.
Conclusion: OGTT is a reliable test that provides explanatory information about impaired glucose metabolism. Waist circumference, BMI and HOMA-IR levels are predictive parameters for the development of diabetes in individuals with prediabetes. With the early diagnosis of these patients and the treatment approaches for this approach, the risk of diabetes development, diabetes mellitus and morbidity may be reduced.
Anahtar Kelimeler: Impaired Fasting Glucose, Oral Glucose Tolerance Test, Diabetes Mellitus